Koefoed Burnham

Western blot analysis showed an upregulation of

-H2AX, increased protein levels of phosphorylated CHK1, TP53, and phosphorylated TP53 in a time-dependent manner, and a downregulated expression of ATR and MDM2.

These results suggested DNA damaging effect and ATR-CHK1-mediated cell cycle arrest of THMGT on MCF-7 cells resulting in…Read more

Although India’s large iron ore reserves are well known, there are still few studies and research on iron ore prospecting in smaller deposits or the deposits with lower grade. Remote sensing concepts are useful to target for mineral exploration, since it covers a large area at low cost. In this research spectral remote sensing and digital image…Read more

Catheter-directed thrombolysis (CDT) and systemic thrombolysis (ST) are used to treat intermediate/high-risk pulmonary embolism (PE) in the absence of comparative safety and effectiveness data. We utilized a large administrative database to perform a comparative safety and effectiveness analysis of catheter-directed versus systemic thrombolysis.…Read more

656 to 0.588 in unresectable PDAC. The log-rank test results showed that advances in surgery significantly improved the median survival from 13 months to 32 months. Radiotherapeutic and chemotherapeutic advancements extended median survival by 12 months and 11 months, respectively, in resectable PDAC. The median survivals were extended by 3 months…Read more

Our findings contribute to a deep understanding of the time distortion consequence of anxiety from a new perspective and offers important insight into the mechanism underlying the effect anxiety has on retrospective time estimation.Cognitive decrements are typical of physiological aging. Among these age-related cognitive changes, visuo-spatial…Read more

M.O.), Yrjö Jahnsson Foundation (6868), Juho Vainio Foundation (E.S.) and Päivikki and Sakari Sohlberg foundation (E.S.).

This work was supported by the Academy of Finland (213506, 265240, 263278, 312073 to J.K., 297908 to M.O. and 341750, 346509 to E.S.), EC FP5 GenomEUtwin (J.K.), National Institutes of Health/National Heart, Lung, and B…Read more

whole.

Atrial fibrillation (AF) is a significant independent risk factor for 1-year mortality in patients with first acute ischemic stroke (AIS). The CHA2DS2-VASc score was initially developed to assess the risk of stroke in patients with AF. Recently, this scoring system has been demonstrated to have clinical value for predicting long-term…Read more

Interleukin-2 (IL-2) and the high-affinity IL-2 receptor (IL-2R) are essential for the survival of regulatory T cells (Tregs) which are the main players in immune tolerance and prevention of autoimmune diseases. Sjögren’s syndrome (SS) is a chronic autoimmune disease predominantly affecting women and is characterised by sicca symptoms including…Read more

n of the patients with booster shots between the inactivated vaccine group and the adenovirus vaccine group.

The protection of inactivated virus vaccine is equivalent to adenovirus vaccine in patients with underlying disease Omicron variant infection, and the titer of IgG antibody in patients with adenovirus vaccine is higher than that in…Read more

The HMM localizes epileptogenic areas (in agreement with EKM) and provides additional information about the relationship between those areas. A key advantage over current methods is that the HMM is a data-driven model, so the output is tuned to each individual. Finally, the model output is intuitive, allowing a user (clinician) to review the…Read more

Although metal-based agents are widely used in disease treatment, precisely controlled metal ions release is still a challenge. Here, we demonstrated a nanoplatform (PAM) to achieve on-demand activation and release of metal ions via controlling oxidation condition by near infrared (NIR) light-inducted photodynamic therapy (PDT). PAM was…Read more