Harrison Noonan

Objective The objective of the present study was to evaluate the effect of low-dose of ketamine, in short-term, on behavioral impairment and acute neuronal death in the cerebral cortex during the acute phase in a model of epileptic mouse induced by pilocarpine.MethodsKetamine was administrated (10 mg/kg) intraperitoneally, 30 min before pil…Read more

We aimed to examine aneurysm hemodynamics with intra-saccular pressure measurement, and compare the effects of coiling, stenting and stent-assisted coiling in proximal segments of intracranial circulation. A cohort of 45 patients underwent elective endovascular coil embolization (with or without stent) for intracranial aneurysm at our department.…Read more

Rarely, it manifests as minimal, spontaneous metrorrhagias in the premenstrual period. Sometimes, metrorrhagias occur during menstruations and are persistent or are caused by sexual intercourses. Isolated endometriosis of the uterine cervix never causes pain. The treatment of this benign condition is based on the destruction or removal of the…Read more

The described methodology could greatly improve pre-screening stage, target selection and drug repurposing efforts in finding other matching targets. HIGHLIGHTS Description and derivation of a first-of-its-kind in silico protein fingerprinting method using B-factors and dihedral angles. Derived Fi-score allows to characterise the whole protein or…Read more

Neoplastic transformation is associated with alterations of the ion transports across plasma and intracellular membranes. These alterations are crucial elements of the phenotypical reprogramming of the transformed cells and may promote adaptation to hypoxia, malignant progression, tumor spreading and metastasis, as well as therapy resistance. The…Read more

Global future land use (LU) is an important input for Earth system models for projecting Earth system dynamics and is critical for many modeling studies on future global change. Here we generated a new global gridded LU dataset using the Global Change Analysis Model (GCAM) and a land use spatial downscaling model, named Demeter, under the five…Read more

5-2) and the highest in Iran (4-5). Sensitivity analyses demonstrated that R0 is sensitive to the applied mean generation time. To the best of the authors’ knowledge, this study is the first to estimate R0 in Qom. To control the epidemic, the reproduction number should be reduced by decreasing the contact rate, decreasing the transmission…Read more

Moreover, advances in previously debated methodological issues, such as pre-registration, reproducibility, statistical power, interpretation of non-significant results, dosage, and sex differences are discussed and integrated with suggestions for the next steps in translating intranasal oxytocin into psychiatric applications.An amendment to this…Read more

The interactions of leukemia cells with the bone marrow (BM) microenvironment is critical for disease progression and resistance to treatment. We have recently found that the vascular adhesion molecule E-(endothelial)-selectin is a key niche component that directly mediates acute myeloid leukemia (AML) chemo-resistance, revealing E-selectin as a…Read more

nion and worldwide and the hurdles to overcome for their broader application in regenerative dentistry.

Global demographic changes, which demonstrate a steady increase of the aging population, highlight the societal need for the application of ATMP-based therapies in the treatment of noncommunicable diseases (NCDs). Although oral diseases, as…Read more